【佳学基因检测】肿瘤坏死因子-α和多囊卵巢综合征：临床、生化和分子遗传学研究基因检测

1年靶向药物要多少钱评价

探索肿瘤基因检测中的数据库比对与基因解码明白《Genet Test Mol Biomarkers》在. 2014 Sep;18(9):605-9.发表了一篇题目为《肿瘤坏死因子-α和多囊卵巢综合征：临床、生化和分子遗传学研究基因检测》肿瘤靶向药物治疗基因检测临床研究文章。该研究由Sujatha Thathapudi , Vijayalakshmi Kodati, Jayashankar Erukkambattu, Anuradha Katragadda, Uma Addepally, Qurratulain Hasan等完成。促进了肿瘤的精准治疗与个性化用药的发展，进一步强调了基因信息检测与分析的重要性。

肿瘤大数据临床研究内容关键词：

多囊卵巢综合征,胰岛素抵抗,肥胖,基因检测,多态性位点

肿瘤靶向治疗基因检测临床应用结果

多囊卵巢综合征分子基因检测研究背景：肿瘤坏死因子-α (TNF-α) 似乎与高雄激素血症 (HA)、增加的胰岛素抵抗 (IR) 和肥胖 (Ob) 相关，这些是多囊卵巢综合征 (PCOS) 的常见特征。生殖科基因检测项目研究的目的是在一组 204 名 PCOS 患者和 204年龄匹配的健康对照。生殖科基因检测研究结果：多囊卵巢综合征PCOS 患者和对照之间存在显着差异。与对照组相比，所有多囊卵巢综合征PCOS 患者的体重指数、腰围、腰臀比、空腹胰岛素、稳态模型评估（HOMA）评分和血清 TNF-α 均升高（p<0.05）。观察到 C-850T 多态性的基因型分布，其中变异 T 等位基因的频率在多囊卵巢综合征PCOS 组中为 0%，在对照组中为 9%（p=0.0032）。生殖科基因检测项目有效性研究结论： 总之，女性多囊卵巢综合征目前的结果表明 TNF -α 系统可能与人群中 TNF-α C850T (rs1799724) 的多态性无关，参与多囊卵巢综合征PCOS 中高雄激素血症 (HA)、肥胖 Ob 和胰岛素抵抗 (IR)的发病机制。

肿瘤发生与复发转移国际数据库描述：

Background: Tumor necrosis factor-alpha (TNF-α) appears to be linked with hyperandrogenism (HA), increased insulin resistance (IR), and obesity (Ob), which were common features noted with polycystic ovarian syndrome (PCOS). Our aim was to study the role of TNF-α in the pathogenesis of IR and Ob in PCOS, as well as a C850T (rs1799724) polymorphism in the promoter region of the TNF-α gene, in a group of 204 PCOS patients and 204 age-matched healthy controls.Results: Significant differences were observed between PCOS patients and controls. All the PCOS had elevated body mass index, waist circumference, waist-to-hip ratio, fasting insulin, homeostatic model assessment (HOMA) score, and serum TNF-α when compared with controls (p<0.05). Genotype distribution for the C-850T polymorphism was observed with the frequency of the variant T allele being 0% in the PCOS group and 9% in the control group (p=0.0032).Conclusions: In conclusion, our present results suggest that the TNF-α system might contribute to the pathogenesis of HA, Ob, and IR in PCOS independent of a polymorphism of the TNF-α C850T (rs1799724) in our population.