【佳学基因检测】MAML2基因重排基因检测在区分组织学相似的腺性牙源性囊肿和骨内粘液表皮样癌中的高效性
dna检测一次多少钱分析
分析肿瘤基因检测及基因突变的改进与提高看到《Oral Surg Oral Med Oral Pathol Oral Radiol》在. 2019 Jun;127(6):e136-e147.发表了一篇题目为《MAML2基因重排基因检测在区分组织学相似的腺性牙源性囊肿和骨内粘液表皮样癌中的高效性》肿瘤靶向药物治疗基因检测临床研究文章。该研究由Rekha Reddy , Mohammed N Islam , Indraneel Bhattacharyya , Donald M Cohen , Sarah G Fitzpatrick , Seema Ganatra 等完成。促进了肿瘤的正确治疗与个性化用药的发展,进一步强调了基因信息检测与分析的重要性。
肿瘤靶向药物测序基因检测研究内容关键词:
腺性牙源性囊肿,GOC,粘液表皮样癌,骨内表皮样癌,断裂荧光原位杂交分析
肿瘤靶向治疗基因检测临床应用结果
多种口腔癌的基因检测分类研究目的:MAML2 在唾液腺中出现的大多数粘液表皮样癌 (MEC) 中得到证实。 粘液表皮样癌 (MEC)也可以发生在骨内 (IMEC)。腺性牙源性囊肿 (GOC) 是一种与 IMEC 组织学重叠的牙源性囊肿。多种口腔癌的基因检测研究旨在确定 MAML2 在区分 IMEC 病例和 GOC 病例方面的高效性。多种口腔癌的基因检测研究设计:在佛罗里达大学的档案中进行了机构审查委员会批准的 IMEC、腺性牙源性囊肿 (GOC) 和具有腺性牙源性囊肿 (GOC) 既往史的 IMEC 的回顾性搜索和阿尔伯塔大学口腔病理学活检服务。从5名患者中选择了9例。对7例MAML2基因重排进行断裂荧光原位杂交分析。多种口腔癌的基因检测结果:4例MAML2基因重排阴性,3例MAML2基因重排阳性。多种口腔癌的基因检测结论:虽然可以得出3例MAML2阳性易位的是IMEC,4例阴性易位不能得出相同的结论。无法确定易位阴性的病例是具有粘液表皮样癌 样岛的腺性牙源性囊肿 (GOC) 还是 MAML2 阴性的 IMEC。因此,MAML2 重排在区分 IMEC 和具有重叠组织学的 GOC 时并不总是高效的。
肿瘤发生与反复转移国际数据库描述:
Objective: MAML2 expression is proven in the majority of mucoepidermoid carcinomas (MECs) arising in salivary glands. MEC can also occur intraosseously (IMEC). Glandular odontogenic cyst (GOC) is an odontogenic cyst with histologic overlap with IMEC. This study aimed to determine the reliability of MAML2 in distinguishing IMEC cases from GOC cases.Study design: An institutional review board-approved retrospective search of IMEC, GOC, and IMEC with prior history of GOC was performed within the archives of the University of Florida and the University of Alberta Oral Pathology Biopsy Services. Nine cases from 5 patients were selected. Break-apart fluorescent in situ hybridization analysis was performed on 7 cases for the presence of MAML2 rearrangement.Results: Four cases had negative MAML2 gene rearrangement, and 3 cases had positive MAML2 gene rearrangement.Conclusions: Although it can be concluded that the 3 cases with positive translocation for MAML2 were IMECs, the same conclusion could not be drawn for the 4 cases with negative translocation. Whether the cases that were negative for translocation were GOCs with MEC-like islands or were MAML2-negative IMECs could not be ascertained. Therefore, MAML2 rearrangement is not always reliable in differentiating IMECs from GOCs with overlapping histology.
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