【佳学基因检测】自杀基因治疗的背景、原理和最新技术简介

做完基因检测 我后悔了—科学性

查重分析《肿瘤个性治疗的方法与措施》《Mol Biotechnol》在 2005 May;30(1):71-88发表了一篇题目为《自杀基因治疗的背景、原理和最新技术简介》肿瘤靶向药物治疗基因检测临床研究文章。该研究由Ion Niculescu-Duvaz, Caroline J Springer等完成。促进了肿瘤的精准治疗与个性化用药的发展，进一步强调了基因信息检测与分析的重要性。

肿瘤靶向药物及精准治疗临床研究内容关键词：

0

肿瘤靶向治疗基因检测临床应用结果

基因治疗被定义为旨在修改细胞的遗传成分以获得治疗益处的技术。自杀基因疗法（或基因导向的酶前药疗法 [GDEPT]）是癌症（尤其是实体瘤）的两步疗法。在第一步中，外源酶的基因通过载体递送至肿瘤。在外源酶表达后，在第二步中给予前药，该前药在肿瘤中被选择性激活。本文讨论了GDEPT的原理和理论背景。特别强调为 GDEPT 开发的酶/前药系统、前药的设计及其激活动力学、旁观者效应的类型和机制及其免疫学意义。还讨论了改进 GDEPT 的可能策略。

肿瘤发生与复发转移国际数据库描述：

Gene therapy is defined as a technology that aims to modify the genetic component of cells to gain therapeutic benefits. Suicide gene therapy (or gene-directed enzyme prodrug therapy [GDEPT]) is a two-step treatment for cancer (especially, solid tumors). In the first step, a gene for a foreign enzyme is delivered to the tumor by a vector. Following the expression of the foreign enzyme, a prodrug is administered during the second step, which is selectively activated in the tumor. This article discusses the principles and the theorectical background of GDEPT. A special emphasis is put on enzyme/prodrug systems developed for GDEPT, the design of prodrugs and the kinetic of their activation, the types and the mechanisms of bystander effect and its immunological implications. The possible strategies to improve GDEPT are also discussed.