【佳学基因检测】癌症糖组学在 3P 医学框架内提供潜在的生物标志物和治疗靶点

做基因检测费用关键点

深究做了备注《Front Endocrinol (Lausanne)》在. 2022 Aug 22;13:970489.发表了一篇题目为《癌症糖组学在 3P 医学框架内提供潜在的生物标志物和治疗靶点》肿瘤靶向药物治疗基因检测临床研究文章。该研究由Yuna Guo, Wenshuang Jia, Jingru Yang, Xianquan Zhan等完成。促进了肿瘤的精准治疗与个性化用药的发展，进一步强调了基因信息检测与分析的重要性。

肿瘤靶向药物及精准治疗临床研究内容关键词：

3P医学,癌症生物标志物,荧光成像,糖基化,免疫化学方法,免疫疗法,凝集素识别,质谱

肿瘤靶向治疗基因检测临床应用结果

糖基化是蛋白质中最重要的翻译后修饰 (PTM) 之一，是自然界中最丰富多样的生物聚合物。聚糖参与癌症发生和发展的多个生物学过程，包括细胞-细胞相互作用、细胞-细胞外基质相互作用、肿瘤侵袭和转移、肿瘤血管生成和免疫调节。作为一种重要的生物标志物，肿瘤相关的糖基化变化已被广泛研究。本文回顾了基于糖基化的生物标志物研究的最新进展，这对于癌症诊断和预后评估很有用。已发现截短的 O-聚糖、唾液酸化、岩藻糖基化和复杂的分支结构是恶性肿瘤中最常见的结构模式。近年来，免疫化学方法、基于凝集素识别的方法、质谱（MS）相关方法和基于荧光成像的原位方法极大地促进了糖组学和糖蛋白生物标志物在各种癌症中的发现和应用潜力。特别是，基于 MS 的蛋白质组学极大地促进了细胞外糖蛋白的综合研究，增加了我们对它们在调节细胞活动中的关键作用的理解。预测、预防和个体化医疗（PPPM；3P医学）是针对不同患者进行早期预测、预防和个体化治疗的有效途径，被誉为21世纪医学发展的新方向，代表着终极目标和最高境界。医学发展阶段。已发现糖基化具有新的诊断、预后甚至治疗潜力。糖基化分析和生物学利用的目的是对医疗保健和医疗实践进行根本性的改变，从而引领医学研究和实践进入3P医学的新时代。关键词：3P医学；癌症生物标志物；荧光成像；糖基化；免疫化学方法；免疫疗法；凝集素识别；质谱。

肿瘤发生与复发转移国际数据库描述：

Glycosylation is one of the most important post-translational modifications (PTMs) in a protein, and is the most abundant and diverse biopolymer in nature. Glycans are involved in multiple biological processes of cancer initiation and progression, including cell-cell interactions, cell-extracellular matrix interactions, tumor invasion and metastasis, tumor angiogenesis, and immune regulation. As an important biomarker, tumor-associated glycosylation changes have been extensively studied. This article reviews recent advances in glycosylation-based biomarker research, which is useful for cancer diagnosis and prognostic assessment. Truncated O-glycans, sialylation, fucosylation, and complex branched structures have been found to be the most common structural patterns in malignant tumors. In recent years, immunochemical methods, lectin recognition-based methods, mass spectrometry (MS)-related methods, and fluorescence imaging-based in situ methods have greatly promoted the discovery and application potentials of glycomic and glycoprotein biomarkers in various cancers. In particular, MS-based proteomics has significantly facilitated the comprehensive research of extracellular glycoproteins, increasing our understanding of their critical roles in regulating cellular activities. Predictive, preventive and personalized medicine (PPPM; 3P medicine) is an effective approach of early prediction, prevention and personalized treatment for different patients, and it is known as the new direction of medical development in the 21st century and represents the ultimate goal and highest stage of medical development. Glycosylation has been revealed to have new diagnostic, prognostic, and even therapeutic potentials. The purpose of glycosylation analysis and utilization of biology is to make a fundamental change in health care and medical practice, so as to lead medical research and practice into a new era of 3P medicine.Keywords: 3P medicine; cancer biomarker; fluorescence imaging; glycosylation; immunochemical method; immunotherapy; lectin recognition; mass spectrometry.