【佳学基因检测】ZEB1：肿瘤转移过程中免疫逃逸的催化剂

基因检测多少钱解析

阅读认识到《Biomed Pharmacother》在. 2022 Sep;153:113490.发表了一篇题目为《ZEB1：肿瘤转移过程中免疫逃逸的催化剂》肿瘤靶向药物治疗基因检测临床研究文章。该研究由Jiahui Lu, Fei Fei, Chenxi Wu, Jie Mei, Junying Xu, Peihua Lu 等完成。促进了肿瘤的精准治疗与个性化用药的发展，进一步强调了基因信息检测与分析的重要性。

肿瘤靶向药物及精准治疗临床研究内容关键词：

急救人员,转移,信号通路,肿瘤免疫,斑马1

肿瘤靶向治疗基因检测临床应用结果

转录因子锌指 E-box 结合同源框 1 (ZEB1) 是上皮间充质转化 (EMT) 的关键诱导剂，并在肿瘤转移中发挥重要作用。它不仅可以促进肿瘤细胞的运动和扩散，还可以促进细胞干性、治疗抵抗、肿瘤转移和免疫逃逸。 ZEB1 的表达受到多种转录前和转录后信号通路和分子的严格调控。越来越多的证据表明蛋白质修饰（例如 ZEB1 的甲基化和乙酰化）也可以影响肿瘤转移。更重要的是，ZEB1诱导免疫抑制细胞和趋化因子进入肿瘤微环境（TME），导致肿瘤免疫抑制微环境的形成。本综述总结了参与 ZEB1 表达的调控因素及其重要作用。本综述涵盖的研究领域有助于为恶性肿瘤靶向ZEB1治疗提供新思路和新治疗见解。转移;信号通路；肿瘤免疫；斑马1。

肿瘤发生与复发转移国际数据库描述：

The transcription factor zinc finger E-box binding homeobox 1 (ZEB1) is a critical inducer of epithelial mesenchymal transformation (EMT) and plays a robust role in tumor metastasis. It can promote not only the movement and diffusion of tumor cells but also cell stemness, treatment resistance, tumor metastasis and immune escape. The expression of ZEB1 is strictly regulated by a variety of pretranscriptional and posttranscriptional signaling pathways and molecules. Increasing evidence indicates that protein modifications such as methylation and acetylation of ZEB1 can also affect tumor metastasis. More importantly, ZEB1 induces immunosuppressive cells and chemokines into the tumor microenvironment (TME), leading to the formation of a tumor immunosuppressive microenvironment. This review summarizes the regulatory factors involved in ZEB1 expression and its important role. The areas of research covered in this review contribute to providing new thoughts and new treatment insights for targeted ZEB1 therapy of malignant tumors.Keywords: EMT; Metastasis; Signaling pathway; Tumor immunity; ZEB1.